Author

Luiz Carlos de Paiva Nogueira da Silva

Fiocruz MinasORCID 0000-0002-4679-9204Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Alessandra Aparecida GuarneriiD· 1 shared Ariel Mariano SilberiD· 1 shared Gabriela Torres MontanaroiD· 1 shared Janaina De Freitas NascimentoiD· 1 shared Letícia MarcheseiD· 1 shared María Julia BarisóniD· 1 shared Rodolpho Ornitz Oliveira SouzaiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Alessandra Aparecida GuarneriORCID

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1 paper

Recent·Most cited

BiochemistryMicrobial CellPeer-reviewedJun 25, 2025

Knocking out histidine ammonia-lyase by using CRISPR-Cas9 abolishes histidine role in the bioenergetics and the life cycle of Trypanosoma cruzi.

Janaina De Freitas Nascimento, María Julia Barisón, Gabriela Torres Montanaro…·Ariel Mariano Silber

This study shows that knocking out histidine ammonia-lyase in Trypanosoma cruzi prevents histidine metabolism, affecting energy production and parasite life cycle.

1 citation

genetic perturbation / CRISPRhost-pathogen & immune response

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