Author

Letícia Marchese

Brazilian Center for Research in Energy and MaterialsORCID 0000-0002-1955-9184Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alessandra Aparecida GuarneriiD· 1 shared Amanda Gonçalves EufrásioiD· 1 shared Ángel Lobo-RojasiD· 1 shared Ariel Mariano SilberiD· 1 shared Artur T. CordeiroiD· 1 shared D. T. Souza GabrieliD· 1 shared F. Catelli MichelleiD· 1 shared Gabriela Torres MontanaroiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Alessandra Aparecida GuarneriORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintAug 6, 2025

Exploring T. cruzi IMPDH as a promising target through Chagas Box screening and AVN-944 inhibition

Ángel Lobo-Rojas, Letícia Marchese, Amanda Gonçalves Eufrásio…·Artur T. Cordeiro

The paper identifies TcIMPDH as a druggable target for Chagas disease and shows AVN-944 has potent inhibition and selectivity in infected cells.

1 citation

proteomicsstatistical model

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BiochemistryMicrobial CellPeer-reviewedJun 25, 2025

Knocking out histidine ammonia-lyase by using CRISPR-Cas9 abolishes histidine role in the bioenergetics and the life cycle of Trypanosoma cruzi.

Janaina De Freitas Nascimento, María Julia Barisón, Gabriela Torres Montanaro…·Ariel Mariano Silber

This study shows that knocking out histidine ammonia-lyase in Trypanosoma cruzi prevents histidine metabolism, affecting energy production and parasite life cycle.

1 citation

genetic perturbation / CRISPRhost-pathogen & immune response

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