Janaina De Freitas Nascimento

An auxin-inducible degron system for trypanosomes

This paper describes the adaptation of an auxin-inducible degron system for trypanosomes by expressing a rice E3 ubiquitin ligase to enable specific protein degradation.

Knocking out histidine ammonia-lyase by using CRISPR-Cas9 abolishes histidine role in the bioenergetics and the life cycle of Trypanosoma cruzi.

This study shows that knocking out histidine ammonia-lyase in Trypanosoma cruzi prevents histidine metabolism, affecting energy production and parasite life cycle.

Intron-loss in Kinetoplastea correlates with a non-functional EJC and loss of NMD factors

This study shows that Trypanosoma brucei lacks a functional EJC and NMD pathway due to intron loss and gene redundancy.

Branched chain amino acids modulate the proteomic profile of Pro-induced differentiation for the infective stages of Trypanosoma cruzi

This study investigates how branched-chain amino acids (BCAAs) affect the proteomic profile of Pro-induced differentiation in Trypanosoma cruzi, revealing metabolic changes linked to reduced infectivity.

On-site ribosome remodeling by locally synthesized ribosomal proteins in axons

The paper shows that ribosomal proteins are synthesized locally in axons and incorporated into ribosomes in a nucleolus-independent manner, regulated by a novel RNA motif.