The paper uses polygenic scores to identify plasma proteins causally linked to cardiometabolic diseases and finds some are targets for existing therapies.

Nature Metabolism · Nov 8, 2021Peer-reviewedGenetics

A Comprehensive Assessment of Demographic, Environmental and Host Genetic Associations with Gut Microbiome Diversity in Healthy Individuals

Petar Šćepanović, Flavia Hodel, Stanislas Mondot, Valentin Partula, Allyson L. Byrd, Christian Hammer, Cécile Alanio, Jacob Bergstedt, Étienne Patin, Mathilde Touvier, Olivier J Lantz, Matthew L. Albert, Darragh Duffy, Lluís Quintana‐Murci, Jacques Fellay

This study identifies non-genetic factors associated with gut microbiome diversity in a cohort of healthy individuals, finding no genome-wide significant genetic associations.

Microbiome · Sep 13, 2019Peer-reviewedGenomics

Human genomics of acute liver failure due to hepatitis B virus infection: an exome sequencing study in liver transplant recipients

Samira Asgari, Nimisha Chaturvedi, Petar Šćepanović, Christian Hammer, Nasser Semmo, Emiliano Giostra, Beat Müllhaupt, Peter Angus, Alexander J. V. Thompson, Darius Moradpour, Jacques Fellay

This study uses exome sequencing to investigate genetic factors contributing to acute liver failure from HBV infection in liver transplant recipients but finds no causal variants.

Journal of Viral Hepatitis · Oct 13, 2018Peer-reviewedGenomics

Genetic factors and age are the strongest predictors of humoral immune responses to common pathogens and vaccines

Petar Šćepanović, Cécile Alanio, Christian Hammer, Flavia Hodel, Jacob Bergstedt, Étienne Patin, Christian Wandall Thorball, Nimisha Chaturvedi, Bruno Charbit, Laurent Abel, Lluís Quintana‐Murci, Darragh Duffy, Matthew L. Albert, Jacques Fellay

This study identifies age, sex, and genetic variants as key predictors of variability in humoral immune responses to pathogens and vaccines.

Genome Medicine · Jul 27, 2018Peer-reviewedGenomics