Shu Mei Teo

Deep learning for polygenic prediction: The role of heritability, interaction type and sample size

This study evaluates deep learning methods for polygenic prediction, showing that MLP benefits most from larger sample sizes and one-hot encoding improves performance across methods.

Integration of polygenic and gut metagenomic risk prediction for common diseases

This study integrates polygenic risk scores and gut metagenomic data to improve prediction of common diseases, showing enhanced predictive performance over conventional risk factors.

Early prediction of liver disease using conventional risk factors and gut microbiome-augmented gradient boosting

This study uses gut microbiome data and machine learning to improve liver disease risk prediction, showing that combining microbiome features with conventional risk factors enhances model performance.

Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases

The paper uses polygenic scores to identify plasma proteins causally linked to cardiometabolic diseases and finds some are targets for existing therapies.

Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy

This study identifies genetic variants with pleiotropic effects on cytokines and related traits using a multivariate genome-wide association analysis.

Non-parametric mixture models identify trajectories of childhood immune development relevant to asthma and allergy

The paper identifies three distinct immune development trajectories in childhood using unsupervised clustering, revealing a high-risk atopic cluster associated with allergic diseases.

Dynamics of the upper airway microbiome in the pathogenesis of asthma-associated persistent wheeze in preschool children

The paper tracks the upper airway microbiome changes in preschool children and links them to asthma-associated persistent wheeze, showing that bacterial shifts precede viral infections and symptoms in sensitized children.

The infant airway microbiome in health and disease impacts later asthma development

The paper examines the infant airway microbiome's role in asthma development by analyzing viral and bacterial communities in nasopharyngeal samples from a birth cohort.