Author

Nicholas A. Watkins

National Health Service

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 3 Genetics· 3

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 6 Research Focus:GWAS / association mapping· 4 Assay:bulk RNA-seq· 2 Assay:GWAS summary statistics· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Emanuele Di AngelantonioiD· 6 shared John DaneshiD· 6 shared Adam S. ButterworthiD· 5 shared David J. RobertsiD· 5 shared Willem Hendrik OuwehandiD· 5 shared Stephen BurgessiD· 4 shared Tao JiangiD· 4 shared Dragana VuckoviciD· 3 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersGenetics

Emanuele Di AngelantonioORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases

Scott C. Ritchie, Samuel A. Lambert, Matthew Arnold, Shu Mei Teo, Sol I. Lim, Petar Šćepanović, Jonathan Marten, Sohail Zahid, Mark D. Chaffin, Yingying Liu, Gad Abraham, Willem Hendrik Ouwehand, David J. Roberts, Nicholas A. Watkins, Brian G. Drew, , Michael Inouye

The paper uses polygenic scores to identify plasma proteins causally linked to cardiometabolic diseases and finds some are targets for existing therapies.

Nature Metabolism · Nov 8, 2021Peer-reviewedGenetics

Genetically predicted levels of the human plasma proteome and risk of stroke: a Mendelian Randomization study

Lingyan Chen, James E. Peters, Bram Peter Prins, Elodie Persyn, Matthew Traylor, Praveen Surendran, Savita Karthikeyan, Ekaterina Yonova‐Doing, Emanuele Di Angelantonio, David J. Roberts, Nicholas A. Watkins, Willem Hendrik Ouwehand, John Danesh, Cathryn M. Lewis, Paola G. Bronson, , Joanna M. M. Howson

This study uses Mendelian randomization to identify plasma proteins associated with stroke risk and potential therapeutic targets.

medRxiv · Oct 22, 2021 · PreprintGenetic & Genomic Medicine

ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study

Dipender Gill, Marios Arvanitis, Paul Carter, Ana I. Hernández Cordero, Brian Jo, Ville Karhunen, Susanna C. Larsson, Xuan Li, Sam M. Lockhart, Amy M. Mason, Evanthia E. Pashos, Ashis Saha, Vanessa Y. Tan, Verena Zuber, Yohan Bossé, , Stephen Burgess

This study uses Mendelian randomization to examine if ACE inhibitors or cardiometabolic risk factors affect lung ACE2 and TMPRSS2 expression or plasma ACE2 levels, finding no overall association.

Royal Society Open Science · Nov 1, 2020Peer-reviewedGenetic & Genomic Medicine

Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

Ming‐Huei Chen, Laura M. Raffield, Abdou Mousas, Saori Sakaue, Jennifer E. Huffman, Arden Moscati, Bhavi Trivedi, Tao Jiang, Parsa Akbari, Dragana Vuckovic, Erik L. Bao, Xue Yun Zhong, Regina Manansala, Véronique Laplante, Minhui Chen, , Ruth J. F. Loos

This study identifies 5,552 blood-cell trait-variant associations across 746,667 individuals from 5 global populations, including 71 novel loci and ancestry-specific variants not found in European ancestry populations.

Cell · Sep 1, 2020Peer-reviewedGenetics

The Polygenic and Monogenic Basis of Blood Traits and Diseases

Dragana Vuckovic, Erik L. Bao, Parsa Akbari, Caleb A. Lareau, Abdou Mousas, Tao Jiang, Ming‐Huei Chen, Laura M. Raffield, Manuel Tardáguila, Jennifer E. Huffman, Scott C. Ritchie, Karyn Mégy, Hannes Ponstingl, Christopher J. Penkett, Patrick K. Albers, , Εvangelos Εvangelou

This study identifies 5,106 new genetic variants associated with blood cell traits using large-scale GWAS, highlighting the polygenic and monogenic basis of hematopoiesis.

Cell · Sep 1, 2020Peer-reviewedGenetic & Genomic Medicine

Genetic Analyses of Blood Cell Structure for Biological and Pharmacological Inference

Parsa Akbari, Dragana Vuckovic, Tao Jiang, Kousik Kundu, Roman Kreuzhuber, Erik L. Bao, Louisa Mayer, Janine Collins, Kate Downes, Michel Georges, Luigi Grassi, José A. Guerrero, Stephen K. Kaptoge, Julian Charles Knight, Stuart Meacham, , William John Astle

This study performs GWAS on blood cell flow-cytometry phenotypes, identifies variant-trait associations, and links them to cellular structures and disease mechanisms.

bioRxiv · Jan 30, 2020 · PreprintGenetics