Chloe B. Fishman

A bacterial TIR-based immune system senses viral capsids to initiate defense

This study identifies how bacterial TIR domains recognize viral capsids to initiate defense by forming complexes that trigger NAD+ depletion.

Recording gene expression order in DNA by CRISPR addition of retron barcodes

This paper introduces a method to record transcriptional event timing in living genomes using CRISPR-integrated retron barcodes.