Santiago C. Lopez

The paper shows that VIPR systems in E. coli mediate competition between phages and their satellite counterparts, with satellites using decoy RNAs to counteract repression.

The paper identifies a bacterial immune pathway where tRNA cleavage generates second messengers that trigger cell death via RNA-guided nuclease activity.

The paper identifies VIPR systems, which use noncontiguous RNA codes for DNA recognition, suggesting an ancient origin of adaptive immunity through viral interactions.

The paper identifies recurrent acquisition of nuclease-protease pairs in bacterial antiviral immunity and shows their proteolytic activation mechanism across different immune systems.

This study identifies SspA as a transcriptional regulator of CRISPR adaptation in E. coli using a CRISPRi-based screen and proposes a model of independent cellular control of adaptation and interference by SspA.

The paper uses high-throughput variant libraries and machine learning to identify design rules for improving retron gene editors in both yeast and human genome editing.

The paper experimentally characterizes retrons to determine their RT-DNA sequences, production rates, and editing efficacy across bacterial, phage, and human genomes.

This paper introduces a method to record transcriptional event timing in living genomes using CRISPR-integrated retron barcodes.

The paper improves retron architectures to enhance DNA production across different organisms, leading to more efficient genome editing.