Zakia Morichaud

Single-stranded DNA drives sigma subunit loading onto RNA polymerase to unlock initiation-competent conformations

The paper investigates how single-stranded DNA facilitates sigma subunit loading onto RNA polymerase, enabling the formation of the open promoter complex in Mycobacterium tuberculosis.

Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization

This study reveals how the {sigma}B factor induces RNAP oligomerization into a supramolecular complex, leading to auto-inhibition of transcription initiation in Mycobacterium tuberculosis.

Anti-pausing activity of region 4 of the RNA polymerase σ subunit and its regulation by σ-remodeling factors

The paper investigates the anti-pausing activity of the σ4 domain of RNA polymerase and its regulation by σ-remodeling factors, showing how it enhances transcription initiation by stabilizing RNA:DNA hybrids.