Laurent Chaloin

This study shows that low-dose exposure to a fungicide mixture in drinking water impairs brain development and induces autism-like behaviors in mouse offspring.

This paper introduces a new HIV-1 latency reversing agent, D10, which activates HIV-1 Tat to induce viral production from latent cells.

This study identifies Syk palmitoylation and desulfenylation as critical for FcγR-mediated phagocytosis by regulating Syk localization, activation, and downstream signaling.

This study identifies TopBP1 condensation inhibitors, showing AZD2858 disrupts ATR signaling and synergizes with chemotherapy in colorectal cancer.

This paper uses molecular dynamics simulations to analyze changes in the RBD/hACE2 interface across SARS-CoV-2 variants, identifying key residues and interactions that contribute to binding stability and variant persistence.

The paper uses molecular dynamics simulations to analyze Spike-ACE2 binding across SARS-CoV-2 variants, revealing conformational changes and variant-specific binding differences.

This study reveals how the {sigma}B factor induces RNAP oligomerization into a supramolecular complex, leading to auto-inhibition of transcription initiation in Mycobacterium tuberculosis.