Author
Centre National de la Recherche ScientifiqueORCID 0000-0003-3124-7586Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Rishi Kishore Vishwakarma, N. Marechal, Zakia Morichaud…·Konstantin L. Brodolin
The paper investigates how single-stranded DNA facilitates sigma subunit loading onto RNA polymerase, enabling the formation of the open promoter complex in Mycobacterium tuberculosis.
Zakia Morichaud, Stefano Trapani, Rishi Kishore Vishwakarma…·Konstantin L. Brodolin
This study reveals how the {sigma}B factor induces RNAP oligomerization into a supramolecular complex, leading to auto-inhibition of transcription initiation in Mycobacterium tuberculosis.
Konstantin L. Brodolin, Zakia Morichaud
The paper investigates the anti-pausing activity of the σ4 domain of RNA polymerase and its regulation by σ-remodeling factors, showing how it enhances transcription initiation by stabilizing RNA:DNA hybrids.