Corinne Lionne

An acyclic nucleoside phosphonate effectively blocks the egress of the malaria parasite by inhibiting the synthesis of cyclic GMP.

This study identifies UA2239, an acyclic nucleoside phosphonate, as a first-in-class antimalarial that inhibits parasite egress by targeting guanylate cyclase, with dual anti-growth and anti-transmission effects.

Structural and molecular basis of resistance to aminoglycoside antibiotics by APH(3')-IIb from Pseudomonas aeruginosa

This study functionally and structurally characterizes APH(3')-IIb, an enzyme from Pseudomonas aeruginosa that confers resistance to aminoglycoside antibiotics.

Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization

This study reveals how the {sigma}B factor induces RNAP oligomerization into a supramolecular complex, leading to auto-inhibition of transcription initiation in Mycobacterium tuberculosis.

wTSA-CRAFT : an open-access web server for rapid analysis of thermal shift assay experiments

wTSA-CRAFT provides a web server for rapid analysis of thermal shift assays with a graphical interface, enabling buffer condition optimization for proteins like APH(3)-IIb.