Author
Massachusetts General HospitalORCID 0000-0002-4706-3071Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Laura E. König, Steve Rodriguez, Clemens B. Hug…·Mark W. Albers
The paper identifies TYK2 as a potential therapeutic target for neurodegenerative diseases by linking cdsRNA-induced inflammation to interferon signaling and demonstrating protective effects of TYK2 inhibitors.
Aaron Held, Paxton Major, Aslı Şahin…·Kristi A. Wharton
The paper identifies sensory feedback defects as an early event in ALS motor dysfunction in a Drosophila model and shows BMP signaling in proprioceptors can alleviate motor deficits.
Steven Rodriguez, Benjamin R. Schrank, Aslı Şahin…·Mark W. Albers
The paper shows that cytoplasmic double-stranded RNA (cdsRNA) from C9ORF72 expansions in ALS-FTD brains triggers IFN-I signaling and neuronal death through a viral-mimetic mechanism.