Author

Steve Rodriguez

Harvard UniversityORCID 0000-0002-2708-5791Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Approach:machine learning (classical)· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Mark W. AlbersiD· 3 shared Peter Karl SorgeriD· 3 shared Artem SokoloviD· 2 shared Aslı ŞahiniD· 2 shared Bradley T. HymaniD· 2 shared Clemens B. HugiD· 2 shared George ZhouiD· 2 shared Alan GuoiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersNeuroscience

Mark W. AlbersORCID

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Author profile →

4 papers

Recent·Most cited

RNA Editing of DEGS1 Links Genetic Risk to Ceramide Dysregulation and Astrocyte Toxicity in ALS

Alan Guo, Samuel Lessard, Lilu Guo, Melody Li, Disha Sood, Rachel Passaro, Jeremy Huang, Clément Chatelain, Emanuele de Rinaldis, Khader Shameer, Bailin Zhang, James C. Dodge, Steven Rodriguez

bioRxiv · Sep 22, 2026 · PreprintNeuroscience

TYK2 as a novel therapeutic target in Alzheimer Disease

Laura E. König, Steve Rodriguez, Clemens B. Hug, Shayda Daneshvari, Alexander Chung, Gary Andrew Bradshaw, Aslı Şahin, George Zhou, Robyn J. Eisert, Federica Piccioni, Sudeshna Das, Marian Kalocsay, Artem Sokolov, Peter Karl Sorger, David E. Root, Mark W. Albers

The paper identifies TYK2 as a potential therapeutic target for neurodegenerative diseases by linking cdsRNA-induced inflammation to interferon signaling and demonstrating protective effects of TYK2 inhibitors.

bioRxiv · Jun 4, 2024 · PreprintNeuroscience

Machine Learning Identifies Novel Candidates for DrugRepurposing in Alzheimer's Disease

Steve Rodriguez, Clemens B. Hug, Petar V. Todorov, Nienke Moret, Sarah A. Boswell, Kyle E. Evans, George Zhou, Nathan T. Johnson, Bradley T. Hyman, Peter Karl Sorger, Mark W. Albers, Artem Sokolov

The paper presents a machine learning framework to identify FDA-approved drugs for repurposing in Alzheimer's Disease by analyzing gene lists associated with disease severity and molecular mechanisms.

Nature Communications · Feb 15, 2021Peer-reviewedNeuroscience

Genome-encoded Cytoplasmic Double-Stranded RNAs, Found in C9ORF72 ALS-FTD Brain, Provoke Propagated Neuronal Death

Steven Rodriguez, Benjamin R. Schrank, Aslı Şahin, Hawra J. Al Lawati, Isabel M. Costantino, Eric G. Benz, Darian Fard, Alefiya Dhilla Albers, Luxiang Cao, Alexis C. Gomez, Elena Ratti, Merit Cudkowicz, Matthew P. Frosch, Michael E. Talkowski, Peter Karl Sorger, , Mark W. Albers

The paper shows that cytoplasmic double-stranded RNA (cdsRNA) from C9ORF72 expansions in ALS-FTD brains triggers IFN-I signaling and neuronal death through a viral-mimetic mechanism.

bioRxiv · Jan 19, 2018 · PreprintNeuroscience