Author

Askar A. Kleefeldt

European Molecular Biology LaboratoryORCID 0000-0002-1067-7782Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1

Frequent Co-Authors

André MateusiD· 1 shared Andrew F. JarnuczakiD· 1 shared Anthony D. HilliD· 1 shared Cicely F. Day· 1 shared Cristina ViéiteziD· 1 shared Danielle L. SwaneyiD· 1 shared David OchoaiD· 1 shared Fabian B. H. RehmiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenomics

André MateusORCID

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2 papers

Recent·Most cited

Escherichia coli with a 57-codon genetic code

Wesley E. Robertson, Fabian B. H. Rehm, Martin Spinck, Raffael L. Schumann, Rongzhen Tian, Wei Liu, Yangqi Gu, Askar A. Kleefeldt, Cicely F. Day, Kim C. Liu, Yonka Christova, Jérôme F. Zürcher, Franz Leonard Böge, Jakob Birnbaum, Linda van Bijsterveldt, Jason W. Chin

This paper describes the creation of a synthetic Escherichia coli strain with a 57-codon genetic code by recoding 105 codons in a 4 Mb synthetic genome.

Science · Jul 31, 2025Peer-reviewedSynthetic Biology

The functional landscape of the human phosphoproteome

David Ochoa, Andrew F. Jarnuczak, Cristina Viéitez, Maja Gehre, Margaret Soucheray, André Mateus, Askar A. Kleefeldt, Anthony D. Hill, Luz García‐Alonso, Frank Stein, Nevan J. Krogan, Mikhail M. Savitski, Danielle L. Swaney, Juan Antonio Vizcaíno, Kyung‐Min Noh, Pedro Beltrão

The paper creates a comprehensive human phosphoproteome by integrating 6,801 phospho-enriched mass spectrometry experiments and prioritizes functional phosphosites using machine learning.

Nature Biotechnology · Dec 9, 2019Peer-reviewedGenomics