Fraser T. Sparks

Maximally selective single cell target for circuit control in epilepsy

The paper identifies superhub cells in neural networks that, when targeted, more effectively stabilize epileptic networks compared to traditional hub cells.

Offline Memory Reactivation Promotes the ConsolidationOf Spatially Unbiased Long-Term Cognitive Maps

The paper shows that offline memory reactivation stabilizes long-term spatial representations by counteracting reward-related biases, promoting comprehensive cognitive maps.

Adult-born granule cells support pathological microcircuits in the chronically epileptic dentate gyrus

This study investigates how adult-born granule cells contribute to epileptic network activity in the dentate gyrus using in vivo calcium imaging and neural topic modeling.

A zero-inflated gamma model for post-deconvolved calcium imaging traces

The paper introduces a zero-inflated gamma model for deconvolved calcium imaging traces, showing it outperforms simpler models in simulated and real neural data.

Normal CA1 place fields but discoordinated network discharge in a Fmr1-null mouse model of fragile X syndrome

The paper examines hippocampal place cell activity in Fmr1-null mice, finding normal place fields but disrupted network coordination, suggesting impaired ensemble coding in FXS.

Control of recollection by slow gamma dominating mid-frequency gamma in hippocampus CA1

The paper identifies slow gamma dominance over mid-frequency gamma in hippocampus CA1 as an electrophysiological signature of recollection in mice, linking it to cognitive inflexibility in Fmrl-null mice.