Pengcheng Zhou

NORAD orchestrates KLC1-mediated SFPQ transport via liquid-liquid phase separation

This study identifies NORAD as a regulator of axonal transport through liquid-liquid phase separation, showing its role in SFPQ transport and neuronal function.

Multi-region calcium imaging in freely behaving mice with ultra-compact head-mounted fluorescence microscopes

This paper introduces TINIscope, a compact head-mounted microscope for simultaneous calcium imaging in multiple brain regions of freely behaving mice, demonstrating its ability to record over 1000 neurons across four hippocampal subregions.

maskNMF: A denoise-sparsen-detect approach for extracting neural signals from dense imaging data

maskNMF improves demixing of dense calcium imaging data by denoising, sparsening, and using constrained non-negative matrix factorization to accurately recover neural activity.

Spatial Tracking Across Time (STAT): Tracking Neurons Across In-Vivo Imaging Sessions through Optimizing Local Neighborhood Motion Consistency

The paper introduces a method to track neurons across multiple in-vivo imaging sessions without requiring full field-of-view registration, validated on simulated and experimental datasets.

Improved blind demixing methods for recovering dense neuronal morphology from barcode imaging data

This study develops blind demixing methods and a neural network to recover neuronal morphology from barcode imaging data, showing accurate recovery is feasible with sufficient barcode signal density.

Prepronociceptin-expressing neurons in the extended amygdala signal darting away from an aversive odor

The paper investigates the role of PnocBNST neurons in encoding behavioral responses to aversive and rewarding odors in mice using calcium imaging and optogenetics.

Multiscale and multimodal reconstruction of cortical structure and function

The paper presents a semi-automated reconstruction of mouse primary visual cortex from electron microscopy data, revealing structural and functional relationships in cortical circuits.

EASE: EM-Assisted Source Extraction from calcium imaging data

The paper introduces EASE, a method that matches calcium imaging signals to EM-derived cell segments in mouse visual cortex, enabling dendritic functional analysis and denoising.

A zero-inflated gamma model for post-deconvolved calcium imaging traces

The paper introduces a zero-inflated gamma model for deconvolved calcium imaging traces, showing it outperforms simpler models in simulated and real neural data.

CaImAn: An open source tool for scalable Calcium Imaging data Analysis

CaImAn, an open-source library, automates motion correction, source extraction, deconvolution and cross-session registration for calcium imaging, detecting neurons near human level (F1 0.75 batch, 0.76 online).

The central amygdala controls learning in the lateral amygdala

The paper identifies a specific class of central amygdala neurons that are essential for synaptic plasticity in the lateral amygdala during learning.