Andrew Frederick Hemphill

A new semi-automated, motility-based screening assay for discovery of compounds with activity against the juvenile stage of Fasciola hepatica

This paper introduces a semi-automated motility-based assay to screen compounds against Fasciola hepatica juveniles, identifying three new compounds with nanomolar activity.

Repurposing Niclosamide Ethanolamine for Alveolar Echinococcosis Reveals a Disconnect Between In Vitro Efficacy and In Vivo Outcome

This study tests niclosamide ethanolamine (NEN) as a treatment for alveolar echinococcosis, finding strong in vitro efficacy but no significant in vivo effect in mice.

Bumped kinase inhibitor BKI-1708 interferes in cytokinesis and drives baryzoite stage conversion in the cyst-forming apicomplexan parasites Toxoplasma gondii, Neospora caninum and Besnoitia besnoiti

This study shows that BKI-1708 induces baryzoite formation in T. gondii, N. caninum, and B. besnoiti, which exhibit distinct phenotypic and proteomic features and lack complete cytokinesis.

Preimaginal development of Aedes aegypti in brackish water produces adult mosquitoes with thicker cuticles and greater insecticide resistance

This study shows that Aedes aegypti mosquitoes developing in brackish water have thicker cuticles and higher insecticide resistance compared to those developing in fresh water.

Single- and duplex TaqMan-quantitative PCR for determining the copy numbers of integrated selection markers during site-specific mutagenesis in Toxoplasma gondii by CRISPR-Cas9

The paper develops single and duplex TaqMan qPCR methods to accurately quantify integrated selection markers in Toxoplasma gondii CRISPR-Cas9 knockouts.