Andrea H. Bild

A novel combination therapy for ER+ breast cancer suppresses drug resistance via an evolutionary double-bind

The paper develops a combination therapy for ER+ breast cancer that uses an evolutionary double-bind strategy to suppress drug resistance.

Phylogenetic inference from single-cell RNA-seq data

PhylinSic reconstructs phylogenetic relationships from scRNA-seq data to model tumor evolution and identify subclones and lineage-specific gene expression patterns.

Simplifying the development of portable, scalable, and reproducible workflows

The paper introduces ToolJig, a web application that simplifies creating and validating Common Workflow Language (CWL) documents for reproducible bioinformatics workflows.

Knowledge-based classification of fine-grained immune cell types in single-cell RNA-Seq data with ImmClassifier

ImmClassifier improves fine-grained immune cell type classification in scRNA-Seq data with higher recall and precision than existing tools.

Exploiting collateral sensitivity controls growth of mixed culture of sensitive and resistant cells and decreases selection for resistant cells

The paper shows that combining ribociclib and adavosertib reduces growth of mixed cancer cell cultures and limits resistance development.