Vince Kornél Grolmusz

A novel combination therapy for ER+ breast cancer suppresses drug resistance via an evolutionary double-bind

The paper develops a combination therapy for ER+ breast cancer that uses an evolutionary double-bind strategy to suppress drug resistance.

Ecological interactions in breast cancer: Cell facilitation promotes growth and survival under drug pressure

The paper shows that drug-sensitive breast cancer cells benefit from co-culture with resistant cells, which produce estradiol, leading to increased survival and resistance under treatment.

Exploiting collateral sensitivity controls growth of mixed culture of sensitive and resistant cells and decreases selection for resistant cells

The paper shows that combining ribociclib and adavosertib reduces growth of mixed cancer cell cultures and limits resistance development.