Lance T. Pflieger

A Biolink-compliant graph (∼15 million nodes, ∼113 million edges) adds RefMet and LIPID MAPS metabolite and lipid classifications, plus polygenic score and clinical data element entities, to Translator content.

The paper introduces a method to standardize correlation coefficients across batches in multi-omic data, improving clustering and biological signal discovery by removing batch-specific biases.

This study uses multiomic analysis to identify compartmentalized immune responses and tissue-vascular signatures in Lyme disease, linking local immune processes to systemic symptoms.

The paper validates and expands a serum protein signature associated with APOE genotypes, identifying new protein associations and potential targets for Alzheimer's disease prevention.

This study uses spatial single-cell analysis to identify 10 cell phenotypes in stage III colorectal cancers and links specific spatial features to recurrence risk.

The paper identifies APOE genotype-related metabolite associations with biological age and bioenergetics in humans, showing counterintuitive patterns in {varepsilon}2 and {varepsilon}4 carriers.

ImmClassifier improves fine-grained immune cell type classification in scRNA-Seq data with higher recall and precision than existing tools.

The paper shows that combining ribociclib and adavosertib reduces growth of mixed cancer cell cultures and limits resistance development.