Matthias Munz

This study creates an integrated single-cell atlas of human atherosclerotic plaques using scRNA-seq data, enabling accurate cell type annotation and downstream analyses.

A coronary artery disease GWAS of 181,522 cases among 1,165,690 participants yields 241 associations (54 new); an eight-predictor consensus nominates 185 candidate causal genes, 94 with ≥3 predictors.

The paper introduces MouseFM, a tool for in silico fine-mapping of genetic variants and genes using inbred mouse strain data, and demonstrates its application to identify candidate variants for specific phenotypes.

Qtlizer annotates GWAS variants with gene expression and protein abundance QTLs, revealing limitations of current cis-distance thresholds and enriching for housekeeping genes.

The paper presents the first de novo assembled Egyptian genome and population-based genetic variation data, highlighting differences in allele frequencies and linkage disequilibrium between Egyptians and Europeans.

The paper identifies cis-epistasis at the LPA locus involving two SNPs that interact to modulate coronary artery disease risk and related traits.