Zouhair Aherrahrou

C3a receptor signalling in ObRb-expressing neurons promotes leptin resistance and obesity-associated cardiac remodelling

This study identifies C3aR signaling in ObRb-expressing neurons as a pathway contributing to leptin resistance and obesity-related cardiac remodeling, with potential therapeutic implications.

Deficiency of ZC3HC1 modulates vascular smooth muscle cell phenotype and increases neointima formation

This study investigates how ZC3HC1 deficiency affects vascular smooth muscle cell behavior and neointima formation using in vitro and in vivo models.

Cigarette smoking upregulates vascular expression of the novel atherosclerosis risk factor ADAMTS-7

This study shows cigarette smoke increases vascular ADAMTS7 expression through CCL17-CCR4 signaling, linking smoking to atherosclerosis via a novel gene-environment interaction.

The novel coronary artery disease risk factor ADAMTS-7 modulates atherosclerotic plaque formation by degradation of TIMP-1

This study identifies ADAMTS-7 as a risk factor for atherosclerosis by degrading TIMP-1, reducing its inhibition of MMP-9 and promoting collagen degradation.

In silico candidate variant and gene identification using inbred mouse strains

The paper introduces MouseFM, a tool for in silico fine-mapping of genetic variants and genes using inbred mouse strain data, and demonstrates its application to identify candidate variants for specific phenotypes.