This study identifies shared genetic variants between ADHD and migraine, showing pleiotropy and associations with neuroimmune and neurodevelopmental pathways.

medRxiv · Jan 13, 2026 · PreprintGenetic & Genomic Medicine

Multi-polygenic scores for externalizing behavior in schoolchildren

Uxue Zubizarreta‐Arruti, María Soler Artigas, Rosa Bosch, Judit Cabana‐Domínguez, Natalia Llonga, Pau Carabí‐Gassol, Valeria Macias‐Chimborazo, Manuel Donato Rodríguez-Romero, Mireia Pagerols, Èlia Pagespetit, Raquel Prat, Júlia Puigbó, Josep Antoni Ramos‐Quiroga, Miguel Casas, Silvia Alemany, Marta Ribasés

This paper develops multi-polygenic scores to predict externalizing behavior in children, finding that combining multiple PGSs increases variance explained and that socioeconomic status moderates this effect.

medRxiv · Dec 20, 2025 · PreprintGenetic & Genomic Medicine

Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder

Tracey van der Veen, Markos Tesfaye, Jessica Mei Kay Yang, Toni A. Boltz, Friederike Sophie David, Shane Crinion, Maria Koromina, Till F. M. Andlauer, Tim B. Bigdeli, Brandon J. Coombes, Tiffany A. Greenwood, Georgia Panagiotaropoulou, Nadine Parker, Heejong Sung, Nicholas James Bass, , Melvin G. McInnis

This study identifies genetic risk loci and factors underlying clinical subtypes of bipolar disorder using GWAS and meta-analysis.

medRxiv · Jun 23, 2025 · PreprintGenetic & Genomic Medicine

Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder

Nora I Strom, Zachary F Gerring, Marco Galimberti, Dongmei Yu, Matthew Halvorsen, Abdel Abdellaoui, Cristina Rodriguez‐Fontenla, Julia Sealock, Tim Bigdeli, Jonathan R Coleman, Behrang Mahjani, Jackson G Thorp, Katharina Bey, Christie L Burton, Jurjen J Luykx, , Bjarne K. A. Hansen

This study identifies 30 genome-wide significant loci for obsessive-compulsive disorder (OCD) using a large GWAS, linking risk to specific brain cell types and shared genetic risk with other psychiatric and non-psychiatric traits.

Research at the University of Copenhagen (University of Copenhagen) · Jan 1, 2025Peer-reviewedGenetic & Genomic Medicine

Disentangling heterogeneity in Substance Use Disorders: Insights from Genome-Wide Polygenic Scores

Laura Vilar‐Ribó, Silvia Alemany, Judit Cabana‐Domínguez, Natalia Llonga, Lorena Arribas, Lara Grau‐López, Constanza Daigre, Bru Cormand, Noèlia Fernàndez-castillo A, Josep Antoni Ramos‐Quiroga, María Soler Artigas, Marta Ribasés

This study investigates SUD heterogeneity by analyzing polygenic scores for psychiatric traits and their interactions with environmental factors in a deeply phenotyped SUD cohort.

medRxiv · Nov 11, 2023 · PreprintGenetic & Genomic Medicine

The pleiotropic contribution of genes in dopaminergic and serotonergic pathways to addiction, aggression, and related behavioural traits

Ester Antón-Galindo, Judit Cabana‐Domínguez, Bàrbara Torrico, Roser Corominas, Bru Cormand, Noèlia Fernàndez-castillo A

This study identifies pleiotropic effects of dopaminergic and serotonergic genes on addiction, aggression, and related behaviors through GWAS and TWAS analyses across multiple datasets.

medRxiv · May 3, 2023 · PreprintGenetic & Genomic Medicine

Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new genetic hits

Silvia Alemany, María Soler Artigas, Judit Cabana‐Domínguez, Dana Fakhreddine, Natalia Llonga, Laura Vilar‐Ribó, Amanda Rodríguez‐Urrutia, Judit Palacio, Ana María González-Castro, Beatriz Lobo, Carmen Alonso, Magnus Simrén, Javier Santos, Josep Antoni Ramos‐Quiroga, Marta Ribasés

This study identifies 38 new genetic loci for irritable bowel syndrome through a multi-trait genome-wide association analysis, revealing genetic overlaps with mental conditions and potential causal relationships.

medRxiv · Jan 30, 2023 · PreprintGenetic & Genomic Medicine

Comprehensive exploration of the genetic contribution of the dopaminergic and serotonergic pathways to psychiatric disorders

Judit Cabana‐Domínguez, Bàrbara Torrico, Andreas Reif, Noèlia Fernàndez-castillo A, Bru Cormand

This study investigates the genetic contribution of dopaminergic and serotonergic pathways to eight psychiatric disorders using GWAS data from the Psychiatric Genomics Consortium.

Translational Psychiatry · Jan 10, 2022Peer-reviewedGenetic & Genomic Medicine

Exploring Genetic Variation That Influences Brain Methylation In Attention-Deficit/Hyperactivity Disorder

Laura Pineda-Cirera, Anu Shivalikanjli, Judit Cabana‐Domínguez, Ditte Demontis, Veera Manikandan Rajagopal, Anders Dupont Børglum, Stephen V. Faraone, Bru Cormand, Noèlia Fernàndez-castillo A

This study identifies three novel genes associated with ADHD by linking genetic variants to differential DNA methylation and gene expression in brain tissues.

Translational Psychiatry · Oct 3, 2019Peer-reviewedGenetics

Genome-wide association meta-analysis of cocaine dependence: shared genetics with comorbid conditions

Judit Cabana‐Domínguez, Anu Shivalikanjli, Noèlia Fernàndez-castillo A, Bru Cormand

This paper conducts a genome-wide association study of cocaine dependence, finding shared genetic risk factors with comorbid psychiatric conditions.

Progress in Neuro-Psychopharmacology and Biological Psychiatry · Jun 15, 2019Peer-reviewedGenetics