Silvia Alemany

Exploring the genetic overlap between attention-deficit/hyperactivity disorder (ADHD) and migraine

This study identifies shared genetic variants between ADHD and migraine, showing pleiotropy and associations with neuroimmune and neurodevelopmental pathways.

Multi-polygenic scores for externalizing behavior in schoolchildren

This paper develops multi-polygenic scores to predict externalizing behavior in children, finding that combining multiple PGSs increases variance explained and that socioeconomic status moderates this effect.

Genome-wide association study of adolescent-onset depression

This study identifies 52 genetic variants associated with adolescent-onset depression through a large GWAS, revealing age-specific mechanisms and potential drug targets.

Genome-wide analysis of social behaviour in context: a meta-regression approach across social domains, reporters and developmental stages

This study uses genome-wide meta-regression to analyze social behavior across different contexts, ages, and reporters, identifying six genetic loci and showing modest heritability.

Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder

This study identifies genetic risk loci and factors underlying clinical subtypes of bipolar disorder using GWAS and meta-analysis.

Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder

This study identifies 30 genome-wide significant loci for obsessive-compulsive disorder (OCD) using a large GWAS, linking risk to specific brain cell types and shared genetic risk with other psychiatric and non-psychiatric traits.

Epigenetic timing effects on child developmental outcomes: A longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium

This study uses longitudinal meta-regression to examine how DNA methylation effects on child health outcomes vary by timing, finding larger effects in childhood but noisier associations and time-specific signals.

Disentangling heterogeneity in Substance Use Disorders: Insights from Genome-Wide Polygenic Scores

This study investigates SUD heterogeneity by analyzing polygenic scores for psychiatric traits and their interactions with environmental factors in a deeply phenotyped SUD cohort.

Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new genetic hits

This study identifies 38 new genetic loci for irritable bowel syndrome through a multi-trait genome-wide association analysis, revealing genetic overlaps with mental conditions and potential causal relationships.

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills.

This study examines DNA methylation at birth and its association with childhood cognitive skills, finding weak single CpG site associations and one region near DUSP22 linked to non-verbal cognition.

Genetic Association Study of Childhood Aggression across raters, instruments and age

This study conducts a genome-wide association meta-analysis of childhood aggression across multiple raters, instruments, and ages, identifying genetic correlations with various traits but no genome-wide significant SNPs.

Association between DNA methylation and ADHD symptoms from birth to school age: A prospective meta-analysis

This study identifies DNA methylation sites at birth associated with ADHD symptoms later in childhood, but finds no such associations at school age.

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

This paper identifies DNA methylation sites associated with aggression through a meta-analysis of epigenome-wide studies across different age groups and tissues.