María Soler Artigas

Pleiotropic genetic architecture linking schizophrenia and substance use disorders

This study identifies shared genetic architecture between schizophrenia and substance use disorders using GWAS and genomic methods, finding significant genetic correlations and bidirectional causal relationships.

Exploring the genetic overlap between attention-deficit/hyperactivity disorder (ADHD) and migraine

This study identifies shared genetic variants between ADHD and migraine, showing pleiotropy and associations with neuroimmune and neurodevelopmental pathways.

Multi-polygenic scores for externalizing behavior in schoolchildren

This paper develops multi-polygenic scores to predict externalizing behavior in children, finding that combining multiple PGSs increases variance explained and that socioeconomic status moderates this effect.

Genome-wide analysis of social behaviour in context: a meta-regression approach across social domains, reporters and developmental stages

This study uses genome-wide meta-regression to analyze social behavior across different contexts, ages, and reporters, identifying six genetic loci and showing modest heritability.

A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits

The paper identifies novel CNV loci and dose-dependent gene effects across six psychiatric disorders using genome-wide analysis.

Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects

The paper identifies shared and divergent genetic mechanisms across psychiatric disorders using gene-set burden analysis of copy number variants.

Disentangling heterogeneity in Substance Use Disorders: Insights from Genome-Wide Polygenic Scores

This study investigates SUD heterogeneity by analyzing polygenic scores for psychiatric traits and their interactions with environmental factors in a deeply phenotyped SUD cohort.

Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new genetic hits

This study identifies 38 new genetic loci for irritable bowel syndrome through a multi-trait genome-wide association analysis, revealing genetic overlaps with mental conditions and potential causal relationships.

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

This study identifies genetic loci associated with suicide attempts and shows shared genetic architecture with psychiatric disorders and non-psychiatric risk factors.

Genetic Association Study of Childhood Aggression across raters, instruments and age

This study conducts a genome-wide association meta-analysis of childhood aggression across multiple raters, instruments, and ages, identifying genetic correlations with various traits but no genome-wide significant SNPs.

Shared genetic background between children and adults with attention deficit/hyperactivity disorder

This study identifies nine new genetic loci associated with ADHD and shows shared genetic architecture between childhood and adult ADHD.

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

The paper identifies 279 new genetic signals for lung function across multiple ancestries, showing associations with COPD and pleiotropic effects.

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

The paper identifies 9 novel genetic loci, including low-frequency variants in TP53, associated with head circumference and intracranial volume in up to 46,000 individuals.