Programmable eukaryotic protein expression with RNA sensors
Kaiyi Jiang, Jeremy G. Koob, Xi Dawn Chen, Rohan N. Krajeski, Yifan Zhang, Lukas Villiger, Wenyuan Zhou, Omar O. Abudayyeh, Fei Chen, Jonathan S. Gootenberg
This paper introduces RADARS, a programmable RNA-sensing technology that uses ADAR-mediated RNA editing to control protein expression based on target RNA transcripts in mammalian cells, with applications in gene therapy and synthetic biology.
bioRxiv · Jan 26, 2022 · PreprintGenomics