Wenyuan Zhou

This study characterizes the RNA-guided nuclease-protease complex Cas7-11-Csx29, showing target RNA binding activates Csx29 to cleave Csx30, leading to cell death.

This paper introduces RADARS, a programmable RNA-sensing technology that uses ADAR-mediated RNA editing to control protein expression based on target RNA transcripts in mammalian cells, with applications in gene therapy and synthetic biology.

This paper introduces a method to control CRISPR/Cas9 activity using light-activated guide RNAs, enabling precise spatiotemporal gene editing in cells and zebrafish embryos.