Dan Ilya Piraner

This paper introduces SNIPR, a synthetic receptor that responds to soluble ligands, enabling targeted CAR T-cell therapy and synthetic cell signaling.

The paper designs EndoTags to trigger endocytosis and degradation of target proteins, enabling tissue-specific targeting and therapeutic applications.

This paper designs and demonstrates synthetic receptors for tunable gene regulation in therapeutic cells, enabling customizable and clinical-ready gene control.

This paper introduces thermomers, temperature-controlled protein dimerization domains that enable remote control of intracellular interactions in various biological contexts.