Author

Kai Kretzschmar

University of WürzburgORCID 0000-0002-4745-6684Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:deep learning· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Lili Szabó· 2 shared Nadja Harnischfeger· 2 shared Stefan Hartmann· 2 shared Adam J. KimpleiD· 1 shared Aditya PratapaiD· 1 shared Alexander V. PredeusiD· 1 shared Alexandre Fernandes· 1 shared Ameer GhodkeiD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

Lili Szabó

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3 papers

Recent·Most cited

NELLY enables patient-centric drug prioritization through interpretable drug-conditioned gene weighting

C Peralta Viteri, Nadja Harnischfeger, Lili Szabó, Stefan Hartmann, Kai Kretzschmar

This paper introduces NELLY, a deep learning model that prioritizes patient-specific therapies by integrating transcriptomic and chemical data, outperforming existing methods in drug response prediction.

bioRxiv · Aug 26, 2026 · PreprintCancer Biology

The Immunoregulatory Architecture of the Adult Oral Cavity

Bruno Fernandes Matuck, Khoa Huynh, Diana Pereira, Quinn T. Easter, XiuYu Zhang, Meik Kunz, Nikhil M Kumar, Aditya Pratapa, Brittany Rupp, Ameer Ghodke, Alexander V. Predeus, Alexandre Fernandes, Lili Szabó, Stefan Hartmann, Nadja Harnischfeger, , Kevin M. Byrd

This paper presents a single-cell and spatial proteotranscriptomic atlas of human oral tissues, identifying fibroblasts as key immunoregulatory hubs and revealing changes in disease states.

Cell Press Blue · Mar 23, 2026Peer-reviewedCell Biology

Modelling cancer immunomodulation using epithelial organoid cultures

Yotam E. Bar-Ephraim, Kai Kretzschmar, Priyanca Asra, Evelien de Jongh, Kim E. Boonekamp, Jarno Drost, Joost van Gorp, Apollo Pronk, Niels Smakman, Inez J. Gan, Zsolt Sebestyén, Jürgen Kuball, Robert G.J. Vries, Hans Clevers

This study uses CRC organoids to model immune-cancer interactions and assess immunomodulation by co-culturing with cytotoxic T cells.

bioRxiv · Oct 4, 2018 · PreprintCancer Biology