Mirit I. Aladjem

Dynamic Schlafen 11 (SLFN11) expression revealed by single-cell RNA sequencing of clonal human cancer cells

The paper uses single-cell RNA sequencing to show heterogeneous SLFN11 expression in cancer cells, linking it to stress response and genome maintenance.

SCLC TumorMiner: A Genomics Platform for Small Cell Lung Cancer Precision Oncology

SCLC TumorMiner is a genomics platform that provides molecular classification, biomarker identification, and drug-response analysis for small cell lung cancer using integrated datasets from multiple institutions.

TR-107, a novel mitochondrial ClpP agonist, induces robust antitumor activity against preclinical models of adrenocortical carcinoma

This study evaluates TR-107, a mitochondrial ClpP agonist, showing antitumor effects in ACC cell lines and organoids, with synergistic activity when combined with IGF-1R inhibitors.

Microhomology-mediated end joining acts directly on replication forks to repair single-ended double strand breaks

This study shows that microhomology-mediated end joining (MMEJ) repairs single-ended DSBs at replication forks, working with BIR and being regulated by ATR and Pol{theta}.

Metastatic organotropism in small cell lung cancer

This study identifies key cellular programs and pathways driving metastatic organotropism in small cell lung cancer using preclinical models and multiomic profiling.

Bimodal genomic approach predicting Semaphorin 7A (SEMA7A) as prognostic biomarker in adrenocortical carcinoma

This paper identifies SEMA7A as a prognostic biomarker in adrenocortical carcinoma using transcriptome data from TCGA and NCI samples, showing its association with poor prognosis and specific signaling pathways.

Lamin A/C Deficiency Drives Genomic Instability and Poor Survival in Small-Cell Lung Cancer through Increased R-loop Accumulation

This study shows that LMNA deficiency in SCLC increases R-loop accumulation, leading to genomic instability and poor patient survival.

Matrin3 regulates cell proliferation and spindle dynamics by regulating CDC14B alternative splicing

This study identifies Matrin3's role in regulating CDC14B alternative splicing, which affects cell proliferation and mitotic spindle dynamics in colorectal cancer cells.

Dynamics of replication origin over-activation

The paper investigates replication origin over-activation in cancer cells and finds two distinct pools of origins are activated under different conditions.

BAMscale: quantification of DNA sequencing peaks and generation of scaled coverage tracks

BAMscale processes DNA sequencing datasets to generate normalized peak scores and scaled coverage tracks for visualization.

Integrative analysis of pharmacogenomics in major cancer cell line databases using CellMinerCDB

CellMinerCDB integrates pharmacogenomic data from multiple cancer cell line databases to identify drug response determinants, reproducibility, and novel genomic signatures.