Author
Research Institute of the McGill University Health CentreORCID 0000-0002-4777-0497Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Myriam Briki, Caroline Wagner, Vincent Desfontaine…·Laurent Arthur Decosterd
The paper shows human prostaglandin reductases PTGR1 and PTGR2 inactivate the antitubercular drug MCZ by dearomatizing it into H2MCZ, reducing its antimycobacterial activity.
Alexander Jovanovic, Frederick K. Bright, Ahmad Sadeghi…·Lucas Boeck
This study introduces ASCT to assess bacterial killing in real-time and links drug tolerance to clinical outcomes in mycobacterial infections.
Felix Deschner, Melissa Dalcina Chengalroyen, Lauren Ames…·Jennifer E. Herrmann
This study identifies chlorotonils as potent anti-Mtb agents and shows resistance is mediated by MmpR5-MmpL5.
Jacob Pierscianowski, Dustin Duncan, Chunling Blue Lan…·Karine Auclair
This study identifies pantetheinamide compounds that inhibit intracellular Salmonella Typhimurium growth by targeting CoA biosynthesis, showing reduced bacterial burden in a murine model.
Jacob Pierscianowski, Suzana Diaconescu-Grabari, Farhan Rahman Chowdhury…·Karine Auclair
This study investigates how Salmonella Typhimurium metabolizes and responds to itaconate, finding that it primarily detoxifies itaconate rather than using it as a carbon source.