Author

Melissa Dalcina Chengalroyen

University of Cape TownORCID 0000-0002-3712-3587Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Valerie MizrahiiD· 3 shared Carolina MehaffyiD· 2 shared David Michael LewinsohniD· 2 shared Deborah A. LewinsohniD· 2 shared Digby Francis WarneriD· 2 shared Karen M. DobosiD· 2 shared Mabule L. Raphela· 2 shared Mandisa Zuma· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

Valerie MizrahiORCID

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Author profile →

3 papers

Recent·Most cited

Chlorotonils exhibit potent activity against Mycobacterium tuberculosis, while resistance is mediated by MmpR5-MmpL5

Felix Deschner, Melissa Dalcina Chengalroyen, Lauren Ames, Diana Quach, Rodrigo Aguilera Olvera, Barbara Bosch, Anthony Castro, Heather Kim, Karthik Raman, Natalie Thornton, Joshua Wallach, Fernanda Rodrigues da Costa, R. H. Allen, Andréanne Lupien, Mandisa Zuma, , Jennifer E. Herrmann

This study identifies chlorotonils as potent anti-Mtb agents and shows resistance is mediated by MmpR5-MmpL5.

bioRxiv · Dec 10, 2025 · PreprintMicrobiology

Disruption of riboflavin biosynthesis in mycobacteria establishes 5-amino-6-D-ribitylaminouracil (5-A-RU) as key precursor of MAIT cell agonists

Melissa Dalcina Chengalroyen, Nurudeen Oketade, Aneta H. Worley, Megan Lucas, Luisa María Nieto Ramírez, Mabule L. Raphela, Gwendolyn M. Swarbrick, Paul S. Soma, Mandisa Zuma, Digby Francis Warner, Deborah A. Lewinsohn, Carolina Mehaffy, Erin J. Adams, William H. Hildebrand, Karen M. Dobos, , David Michael Lewinsohn

Deleting early riboflavin genes (ribA2 in both species, ribG in M. smegmatis) sharply reduced MAIT cell activation, while ribH deletion raised recognition of M. tuberculosis only.

PLoS Pathogens · Jul 1, 2025Peer-reviewedImmunology✦ In-depth digest

Modulation of riboflavin biosynthesis and utilization in mycobacteria

Melissa Dalcina Chengalroyen, Carolina Mehaffy, Megan Lucas, Niel Bauer, Mabule L. Raphela, Nurudeen Oketade, Digby Francis Warner, Deborah A. Lewinsohn, David Michael Lewinsohn, Karen M. Dobos, Valerie Mizrahi

This study investigates riboflavin biosynthesis and utilization in mycobacteria by creating conditional knockdowns and analyzing their impact on viability and MAIT cell recognition.

Microbiology Spectrum · Jun 25, 2024Peer-reviewedMolecular Biology