Author

Giorgio Medici

University of BolognaORCID 0000-0002-8531-3887Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

Elisabetta CianiiD· 2 shared Giulia SagonaiD· 2 shared Maurizio GiustettoiD· 2 shared Tommaso PizzorussoiD· 2 shared Alessandra RaspantiiD· 1 shared Alysson Renato MuotriiD· 1 shared Andrea Macioce· 1 shared Anthony BattagliaiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersNeuroscience

Elisabetta CianiORCID

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2 papers

Recent·Most cited

Postnatal Sensory Experience and Barrel Cortex Alterations Anticipate Autistic Traits in a Mouse Model of Cdkl5 Deficiency Disorder

Alessandra Raspanti, Riccardo Pizzo, Antonia Gurgone, Cecilia Giraudo, Giulia Sagona, Andrea Macioce, Anthony Battaglia, Lamprini Katsanou, Debora Comai, Giorgio Medici, Francesco Ferrini, Tommaso Pizzorusso, Elisabetta Ciani, Maurizio Giustetto

This study shows that CDKL5 deficiency in mice leads to sensory processing defects in the barrel cortex and autistic traits, which can be rescued by neonatal CDKL5 replacement.

Progress in Neurobiology · Aug 19, 2026Peer-reviewedNeuroscience

EXPRESSION OF A SECRETABLE, CELL-PENETRATING CDKL5 PROTEIN ENHANCES THE EFFICACY OF AAV VECTOR-MEDIATED GENE THERAPY FOR CDKL5 DEFICIENCY DISORDER.

Giorgio Medici, Marianna Tassinari, Giuseppe Galvani, Stefano Bastianini, Laura Gennaccaro, Manuela Loi, Nicola Mottolese, Sara Alvente, Chiara Berteotti, Giulia Sagona, Leonardo Lupori, Helen Rappe Baggett, Giovanna Zoccoli, Maurizio Giustetto, Alysson Renato Muotri, , Elisabetta Ciani

This study shows that using a secretable TATk-CDKL5 protein in AAV gene therapy improves CDKL5 replacement and functional outcomes in Cdkl5 KO mice compared to native CDKL5 expression.

bioRxiv · Jul 26, 2021 · PreprintNeuroscience