Joshua J. Carter

Structure-guided vaccination elicits broadly neutralizing antibodies targeting the HIV-1 silent face

This study shows that structure-guided vaccination can elicit broadly neutralizing antibodies targeting the HIV-1 silent face, expanding vaccine strategies.

Sustained vaccine exposure elicits more rapid, consistent, and broad humoral immune responses to multivalent influenza vaccines

This study shows sustained delivery of multivalent influenza vaccines via polymer-nanoparticle hydrogels enhances rapid, consistent, and broad humoral immunity against homologous and heterologous strains.

Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach

This study quantifies antibiotic resistance in tuberculosis using genomic data and MIC measurements to identify genetic determinants of resistance and hypersensitivity across multiple drugs.

GenomegaMap: within-species genome-wide dN/dS estimation from over 10,000 genomes

GenomegaMap estimates genome-wide dN/dS ratios across 10,209 tuberculosis genomes to identify selection pressures shaping the pathogen's evolution.

Structure reveals mechanism of CRISPR RNA-guided nuclease recruitment and anti-CRISPR viral mimicry

The paper presents the cryo-EM structure of the type I-F CRISPR surveillance complex and shows a conformational change that exposes a nuclease recruitment helix homologous to an anti-CRISPR protein.