Author

Andrea Spitaleri

IRCCS Ospedale San RaffaeleORCID 0000-0003-3012-3557Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:human· 3 Assay:whole-genome sequencing· 3 Research Focus:differential expression· 2 Research Focus:variant calling· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Daniela María CirilloiD· 3 shared Sabira TahseeniD· 3 shared Stefan NiemanniD· 3 shared Ajit LalvaniiD· 2 shared Alexander S. LachapelleiD· 2 shared Ana Lúıza Gibertoni CruziD· 2 shared Anastasia Sideris KochiD· 2 shared Andrea Maurizio CabibbeiD· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Daniela María CirilloORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

GenomicsNature CommunicationsPeer-reviewedJan 12, 2024

Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach

Ivan Barilar, Simone Battaglia, Emanuele Borroni…·Guy Edward Thwaites

This study quantifies antibiotic resistance in tuberculosis using genomic data and MIC measurements to identify genetic determinants of resistance and hypersensitivity across multiple drugs.

56 citationstop 1%

humanwhole-genome sequencing

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NeurosciencebioRxivPreprintSep 5, 2023

ABCA7 Loss-of-Function Variants Impact Phosphatidylcholine Metabolism in the Human Brain

Djuna Katrina von Maydell, Shannon Wright, Ping‐Chieh Pao…·Li‐Huei Tsai

This study identifies ABCA7 loss-of-function variants' impact on phosphatidylcholine metabolism in human neurons and shows CDP-choline can reverse these effects.

10 citations

humanbulk RNA-seq

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GenomicsAntimicrobial Agents and ChemotherapyPeer-reviewedAug 30, 2021

The role of epistasis in amikacin, kanamycin, bedaquiline, and clofazimine resistance in Mycobacterium tuberculosis complex

Roger Vargas, Luca Freschi, Andrea Spitaleri…·Maha Reda Farhat

The paper demonstrates epistatic interactions in Mycobacterium tuberculosis complex that can reverse antibiotic resistance, specifically showing that eis promoter mutations cannot confer resistance if paired with LoF mutations in the eis coding region.

71 citationstop 4%

whole-genome sequencingstatistical model

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GenomicsMolecular Biology and EvolutionPeer-reviewedMar 10, 2020

GenomegaMap: within-species genome-wide dN/dS estimation from over 10,000 genomes

Daniel J. Wilson, Derrick W. Crook, Tim Peto…·Dick van Soolingen

GenomegaMap estimates genome-wide dN/dS ratios across 10,209 tuberculosis genomes to identify selection pressures shaping the pathogen's evolution.

48 citations

humanwhole-genome sequencing

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