Author

George Philippos

German Cancer Research CenterORCID 0000-0002-8433-9719Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:genome assembly· 1 Organism:human· 1

Frequent Co-Authors

Alexandra Eliassaf· 1 shared Aurélie ErnstiD· 1 shared Batsheva KeremiD· 1 shared Frauke Devens· 1 shared Gianluca SigismondoiD· 1 shared Jan O. KorbeliD· 1 shared Jan Otoničar· 1 shared Jeroen KrijgsveldiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alexandra Eliassaf

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1 paper

Recent·Most cited

P53 deficiency triggers hypertranscription, inducing nucleotide insufficiency causing replication stress, and genomic instability

Wisam Zaatra, George Philippos, Petr Smirnov, Shira Milo, Jan Otoničar, Michelle Chan, Michal Harel, Frauke Devens, Tchelet Goldberg, Alexandra Eliassaf, Karen Grimes, Michal Irony‐Tur Sinai, Gianluca Sigismondo, Tamar Geiger, Jan O. Korbel, , Aurélie Ernst

This study shows that p53 deficiency causes hypertranscription and nucleotide insufficiency, leading to replication stress and genomic instability, including chromothripsis.

bioRxiv · Apr 17, 2025 · PreprintCancer Biology