Spinal Cord Injury Imprints a Glucocorticoid-Driven Failure State in Hematopoietic Stem Cells
Kyleigh A. Rodgers, Elizabeth A.R. Garfinkle, Kristina A. Kigerl…·Phillip G. Popovich
This paper shows spinal cord injury causes hematopoietic stem cells to enter a repressed state due to glucocorticoid surges, leading to long-term hematopoietic failure, which can be reversed by early glucocorticoid receptor blockade.