The paper shows re-replication is a physiological mechanism in human stem cell differentiation, increasing gene copy numbers to meet protein demands during differentiation.

Cell Death Discovery · Jul 29, 2026Peer-reviewedGenomics

Gene amplification during differentiation of mesenchymal stem cells towards chondrocytes

Paula E Schwarz, Magali Cucchiarini, Shusruto Rishik, Andreas Keller, Eckart U. Meese, Ulrike Fischer

The paper investigates gene amplification dynamics during chondrogenic differentiation of human mesenchymal stem cells and finds that amplifications are transient and stage-specific, correlating with proteoglycan deposition patterns.

bioRxiv · Jun 16, 2026 · PreprintDevelopmental Biology

Aging Rhesus Macaque show tissue and sex-specific balance of drifting and coordinated miRNA programs

Shusruto Rishik, Erik Nutma, Nicole Ludwig, Ulrike Fischer, Tanja Tänzer, Stefanie Rheinheimer, Martin Hart, Laura Gröger, Johanna Meerjanssen, Matthias Flotho, Miguel Angel Esteban, Jinte Middeldorp, Andreas Keller

The paper identifies age-related miRNA deregulation patterns in aging rhesus macaques, highlighting tissue and sex-specific changes and cross-species conservation.

bioRxiv · May 12, 2026 · PreprintSystems Biology

A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase

Annika Engel, Viktoria Wagner, Oliver Hahn, Aulden G. Foltz, Micaiah Atkins, Amila Beganovic, Ian Hunter Guldner, Nannan Lu, Aryaman Saksena, Ulrike Fischer, Nicole Ludwig, Eckart U. Meese, Tony Wyss‐Coray, Andreas Keller

The paper creates a spatio-temporal miRNA atlas in mice, identifying age-related miR-155-5p increase driven by microglia, independent of sex.

Nature Communications · May 17, 2025Peer-reviewedMolecular Biology