Ji‐Long Liu

Filamentation and proline inhibition of glutamate kinase

This study investigates the filamentation and proline inhibition mechanisms of Escherichia coli glutamate kinase using cryogenic electron microscopy.

Cytoskeleton Regulates Cytoophidium Dynamics in Drosophila Ovaries

This study investigates cytoophidium dynamics in Drosophila ovaries and finds that cytoskeletal components regulate their assembly and transport.

FMR1 KH0-KH1 Domains Coordinate m6A Binding and Phase Separation in Fragile X Syndrome

This study shows KH0 and KH1 domains of FMR1 work together in m6A binding and phase separation, linking these processes to Fragile X Syndrome pathology.

CTP Drives Human CTPS1 Filamentation

This study identifies CTP as a regulator of hCTPS1 filamentation, revealing its structural basis and evolutionary conservation.

IMPDH Cytoophidia in the Pancreas: Morphological Dynamics and Metabolic Implications

This study examines IMPDH cytoophidia in pancreatic islets under normal and diabetic conditions, showing morphological changes linked to impaired glucose tolerance.

Cytoophidium complexes resonate with cell fates

The paper investigates how cytoophidium complexes formed by different metabolic enzymes relate to cell fates in yeast, showing that blocking CTPS cytoophidium assembly disrupts quiescence and affects NAD biosynthesis.

VitisC: Visualizing interested target via integrated scaffold of cytoophidium

The paper introduces VitisC, a method to visualize small proteins using cryo-EM by attaching them to a filamentous scaffold formed by E. coli CTP synthase, achieving a resolution of 3.39 Å.

Bio-medical Big Data Operating System (Bio-OS): An Integrated Data Mining Environment for Data Intensive Scientific Research

BioOS provides a cloud-native platform for reproducible biomedical research by integrating data, code, tools, and environments into workspaces, enhancing data integrity and accessibility.

Differential cytoophidium assembly between Saccharomyces cerevisiae and Schizosaccharomyces pombe

This study compares cytoophidium assembly in Saccharomyces cerevisiae and Schizosaccharomyces pombe under varying environmental and intracellular conditions, finding differential responses to temperature, pH, and CTPS overexpression.

eCRUIS captures RNA-protein interaction in vitro and in vivo

eCRUIS enhances RNA-protein interaction capture by integrating dCas13d and TurboID, enabling rapid in vitro and in vivo labeling of RNA-binding proteins.

Connecting Hippo pathway and cytoophidia in Drosophila posterior follicle cells

This study shows that Hippo pathway inactivation reduces cytoophidium length and number in Drosophila posterior follicle cells, linking Hippo signaling to CTPS activity.

Dynamic cytoophidia during Drosophila late oogenesis

The paper studies dynamic cytoophidia in Drosophila late oogenesis using live cell imaging, revealing heterogeneity and dynamic patterns in nurse cells and oocytes.

Cytoophidia maintain the integrity of Drosophila follicle epithelium

This study investigates the role of cytoophidia in Drosophila follicle epithelium integrity using a mutation that disrupts cytoophidium formation.

Cytoophidia safeguard binucleation of Drosophila male accessory gland cells

The paper shows that CTP synthase filaments (cytoophidia) are required to maintain binucleation in Drosophila male accessory gland cells.

CTP synthase does not form cytoophidia in Drosophila interfollicular stalks

The paper shows that CTP synthase does not form cytoophidia in Drosophila interfollicular stalk cells, and links this to low Myc levels and resistance to DON treatment.

Detecting apoptosis via DODO

The paper introduces DODO, a degron-based system for detecting biological processes, including apoptosis, through modular sensors and reporters.

Coupling adipose tissue architecture and metabolism via cytoophidia

This study shows that CTPS filaments (cytoophidia) in Drosophila adipose tissue link metabolism and tissue architecture through Collagen IV-Integrin signaling.