Fan‐Yan Wei

The paper identifies oxidative protein states as drivers of metastatic fitness in lung cancer by linking ROS-regulated protein modifications to mitochondrial function and metastasis.

The paper shows that modified adenosines from RNA catabolism are sequentially metabolized to prevent toxicity and maintain metabolic balance.

The paper identifies a novel A3R-selective ligand and reveals structural insights into A3R activation, enabling structure-guided engineering of m6A-insensitive A3R for drug discovery.

This study develops a high-resolution mitochondrial ribosome profiling technique to analyze translation dynamics and regulation in mammals.

The paper identifies m6A as an endogenous ligand for the A3 adenosine receptor, showing it has higher affinity than unmodified adenosine and plays a role in type I allergy.

The paper identifies NSUN2 as a methyltransferase that introduces 5-methylcytidine into mitochondrial tRNAs in mice and humans.