Alexander J. Kral

The Spliceosome Scaffold Component BCAS2 Promotes Pancreatic Cancer Progression through Weak 5 Splice Site Dependent Splicing Regulation

This study identifies BCAS2 as a critical regulator of PDAC progression by promoting alternative splicing of weak 5' splice sites, specifically enhancing SOS1 exon 21 inclusion and RAC-signaling activation.

MYC-Driven Activation of USP39 Enhances SRSF1 Stability and Promotes PDAC Progression

The paper identifies a MYC-USP39-SRSF1 regulatory axis in PDAC that stabilizes SRSF1 and promotes tumor progression, suggesting USP39 as a therapeutic target.

Splice-switching ASOs targeting an Alu-derived exon in the AURKA 5'UTR collapse an SRSF1-AURKA-MYC oncogenic circuit in pancreatic cancer

This study identifies an SRSF1-AURKA-MYC oncogenic circuit in pancreatic cancer and shows that splice-switching ASOs targeting AURKA 5'UTR splicing disrupts this circuit, reducing cell viability and inducing apoptosis.