Author

Frank Bernhard

Goethe University FrankfurtORCID 0000-0002-4860-1783Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:cryo-EM· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Daniel HilgeriD· 2 shared Volker DötschiD· 2 shared Zoe Köck· 2 shared Achilleas S. FrangakisiD· 1 shared Anja Seybert· 1 shared Anna Grimm· 1 shared Arne MölleriD· 1 shared Dovile JanulieneiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Daniel HilgerORCID

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2 papers

Recent·Most cited

BiochemistryStructurePeer-reviewedAug 25, 2025

Cryo-EM structure of a cell-free synthesized full-length human β1-adrenergic receptor in complex with Gs

Felipe Merino, Zoe Köck, Utz H. Ermel…·Frank Bernhard

The paper determines the cryo-EM structure of a full-length human β1-adrenergic receptor in complex with Gs, revealing structural insights into ICL3's role in G protein activation.

3 citations

humancryo-EM

Molecular BiologybioRxivPreprintJul 27, 2023

Cryo-EM structure of cell-free synthesized human histamine H2 receptor coupled to heterotrimeric Gs protein in lipid nanodisc environment

Zoe Köck, Kilian Schnelle, Margherita Persechino…·Frank Bernhard

The paper presents the cryo-EM structure of the human histamine H2 receptor complexed with Gs protein in lipid nanodiscs, revealing insights into ligand binding and G protein coupling mechanisms.

DOI 10.1101/2023.07.27.550782

humanprotein structure