Felipe Merino

Membrane Proteins at Scale: Automated Copolymer Nanodisc Purification for Structure and Function

This paper introduces an automated copolymer screening platform for membrane protein solubilization, showing next-generation copolymers outperform classical ones across multiple human targets.

Cryo-EM structure of a cell-free synthesized full-length human β1-adrenergic receptor in complex with Gs

The paper determines the cryo-EM structure of a full-length human β1-adrenergic receptor in complex with Gs, revealing structural insights into ICL3's role in G protein activation.

Kinetic and structure-based comparisons of silent and stimulatory flagellin interactions with TLR5

The paper compares the binding kinetics and structural features of silent and stimulatory flagellin variants with TLR5, identifying structural differences that explain their distinct immune responses.

Structure of the Lifeact F-actin complex

This paper determines the structure of the Lifeact-F-actin complex and shows how Lifeact competes with other actin-binding proteins, affecting cell morphology.

Cryo-EM structure of the ClpXP protein degradation machinery

This paper presents the first high-resolution cryo-EM structure of ClpXP from Listeria monocytogenes, revealing the binding interface and activation mechanism of the complex.