Cryo-EM structure of a cell-free synthesized full-length human β1-adrenergic receptor in complex with Gs
Felipe Merino, Zoe Köck, Utz H. Ermel, Philipp Dahlhaus, Anna Grimm, Anja Seybert, Jan Kubicek, Achilleas S. Frangakis, Volker Dötsch, Daniel Hilger, Frank Bernhard
The paper determines the cryo-EM structure of a full-length human β1-adrenergic receptor in complex with Gs, revealing structural insights into ICL3's role in G protein activation.
Structure · Aug 25, 2025Peer-reviewedBiochemistry