Arabidopsis REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA Polymerase IV transcription complexes.
Zhongshou Wu, Yan Xue, Shuya Wang, Yuan‐Hsin Shih, Zhenhui Zhong, Suhua Feng, J. E. Draper, Allen P. Lu, Carsten A Hoeke, Jihui Sha, Lu Li, James Akira Wohlschlegel, Keqiang Wu, Steven E. Jacobsen
The paper identifies Arabidopsis REM transcription factors and GDE1 as key regulators of DNA methylation by recruiting RNA Polymerase IV to generate 24nt-siRNAs that direct methylation to specific genomic loci.
Nature Cell Biology · Jun 27, 2025Peer-reviewedPlant Biology