Jihui Sha

Dual-Binding Scaffold RRsS1 Bridges Pol IV Transcripts and DNA Templates for Robust Reproductive siRNA Biogenesis

This study identifies RRsS1 as a dual-binding scaffold that stabilizes Pol IV transcription complexes to enhance siRNA biogenesis in plant reproduction.

J-domain proteins bridge the PKL and ATRX complex to transcription factors to fine-tune gene expression via H3.3 deposition

The paper identifies J-domain proteins as mediators of PKL recruitment to gene promoters, enabling H3.3 deposition and influencing gene expression through interactions with transcription factors and ATRX.

PABPC1 Modulates Immunoglobulin pre-mRNA Alternative Polyadenylation

The paper investigates PABPC1's role in alternative polyadenylation during B cell development, finding it primarily shortens and downregulates its targets in a context-dependent manner.

Proximity proteomics reveals a role for IFI16 during human coronavirus infection

The paper identifies IFI16 as a host protein interacting with SARS-CoV-2 NSP8/NSP10, showing that IFI16 promotes coronavirus infection independently of its role in type I IFN regulation.

Arabidopsis REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA Polymerase IV transcription complexes.

The paper identifies Arabidopsis REM transcription factors and GDE1 as key regulators of DNA methylation by recruiting RNA Polymerase IV to generate 24nt-siRNAs that direct methylation to specific genomic loci.