Author

Nicole N. Thadani

Harvard UniversityORCID 0000-0002-4866-9294Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:protein design· 2 Assay:protein sequence· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

Debora S. MarksiD· 2 shared Samuel LimiD· 2 shared Adam J. RiesselmaniD· 1 shared Alessandro Passera· 1 shared Amir Rafiq KhaniD· 1 shared Benjamin J. FramiD· 1 shared Chris SanderiD· 1 shared Christopher D. BahliD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersSynthetic Biology

Debora S. MarksORCID

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2 papers

Recent·Most cited

Simultaneous enhancement of multiple functional properties using evolution-informed protein design

Benjamin J. Fram, Yang Su, Ian Truebridge, Adam J. Riesselman, John Ingraham, Alessandro Passera, Eve Napier, Nicole N. Thadani, Samuel Lim, Kristen Roberts, Gurleen Kaur, Michael Allen Stiffler, Debora S. Marks, Christopher D. Bahl, Amir Rafiq Khan, , Nicholas Paul Gauthier

This study uses evolutionary models to design highly divergent protein variants with enhanced functional properties while maintaining structure.

Nature Communications · Jun 20, 2024Peer-reviewedSynthetic Biology

Natural and designed proteins inspired by extremotolerant organisms can form condensates and attenuate apoptosis in human cells

Mike T. Veling, Dan T. Nguyen, Nicole N. Thadani, Michela E. Oster, Nathan J. Rollins, Kelly P. Brock, Neville P. Bethel, Samuel Lim, David A. Baker, Jeffrey C. Way, Debora S. Marks, Roger L. Chang, Pamela A. Silver

The paper identifies extremotolerant proteins that form condensates and protect human cells from apoptosis, including a synthetic protein and a region of ApoE.

ACS Synthetic Biology · Feb 18, 2022Peer-reviewedSynthetic Biology