Christopher D. Bahl

MPNN-guided redesign of PET hydrolases with enhanced catalytic activity below the PET glass transition temperature

This paper redesigns PET hydrolase PHL7 using MPNN models to enhance its catalytic activity at lower temperatures, achieving efficiency comparable to its activity at higher temperatures.

Simultaneous enhancement of multiple functional properties using evolution-informed protein design

This study uses evolutionary models to design highly divergent protein variants with enhanced functional properties while maintaining structure.

Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks

The paper presents a framework for ensuring reproducibility in bio-macromolecular modeling through automated benchmarks and a test server, demonstrating its utility for Rosetta and other tools.

Growing Glycans in Rosetta: Accurate de novo glycan modeling, density fitting, and rational sequon design

This paper expands the Rosetta software suite with tools for glycan modeling, density fitting, and rational sequon design, achieving high accuracy in predicting and building glycan structures.