Jaewon Ko

This study identifies homozygous loss-of-function MDGA2 variants in individuals with developmental and epileptic encephalopathy, establishing MDGA2 as a novel gene for this condition.

This study shows that bazedoxifene treatment rescues ASD-like behaviors in male mice with a specific MDGA1 mutation, but not in females.

The paper investigates the role of Slitrk and LAR-RPTP proteins in neuronal migration during mouse cortex development, showing they influence migration independently of synaptic organizer activity.

This study shows that calsyntenin-3 deletion in Purkinje cells reduces inhibitory synapses while increasing excitatory parallel-fiber synapses, suggesting a novel role in regulating excitatory/inhibitory balance.

This study shows that Calsyntenin-3 interacts with specific neurexin variants to promote excitatory synapse development in the hippocampus.

This study shows that Npas4 regulates IQSEC3 expression in SST interneurons, affecting GABAergic synapse function and anxiety-like behavior.

This study shows that presynaptic PTPσ organizes neurotransmitter release at excitatory synapses and affects anxiety-like behaviors.

This study investigates the role of SALM1/LRFN2 in synaptic function and behavior by analyzing Lrfn2-/- mice, finding altered synaptic plasticity, inhibitory synapse development, and social communication behaviors.